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+/+ for COMT AND MTHFR - which b12?


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Just got my daughter's 23andme results back. She is +/+ for COMT V158M and H62H as well as MTHFR A1298C.

 

For COMT she should be taking hydroxyl b12 (or cyanocobamin?) but for MTHFR it is recommended methyl b12. So which do I do? It seems that everything that is recommended for one of the mutations is advised against for the other.

 

She is also +/- for VDR Taq, MAO, MTR, MTRR (also suggests methyl b12), BHMT-02 and 08 and CBS A360A (she does not appear to be very sulfur intolerant).

 

 

For background, she was diagnosed with PANDAS in early March (after several months of increasing OCD behavior) and started Augmentim and then herxed pretty bad. She has high strep and myco p titers.

 

Switched to zithro, started detoxing and switched to a LLMD who suggests a tick borne illness and possible bartonella. Will begin a pulsing abx protocol in a few weeks but first prescribed low dose Luvox to calm her nervous system down a bit. We are also supplementing with CBD hemp oil. That combo of 37.5 mg luvox and 10 drops hemp twice a day has her OCD symptoms under control to the point that most days of the last few weeks have seemed almost "normal" with only a flare every few days.

 

However, one thing that everything we're doing isn't helping is her anxiety. She is on edge all the time. We now realize this is from the COMT, CBS and MTHFR so I really want to address these issues to give her some relief. She is also still slightly constipated and only has a bm every few days. She is taking antifungals for yeast overgrowth.

 

 

So, here is my question: anyone else have a child with COMT and MTHFR? What do you suggest? And what about folate? Is there one she should be taking? Her last test results showed low magnesium, selenium, manganese and molybdenum. She is taking magnesium daily and eating two brazil nuts (read that on Buhner's page) for selenium. Should we be adding manganese and molybdenum too? And I think I read something about P5P b6. What I'd love to start with is something that will make her less anxious b/c that's what is making her life so hard for her right now.

 

My head is spinning. I've been limiting myself to just two hours of "research" a day for sanity sake. I just finished yasko's document and am now moving on to heartfixer.

 

Thanks for reading and for your help. This group has been so good to me.

 

 

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